NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Survivorship

Heart Failure

Know your patient’s fluid volumes and track changes over time to identify the optimal fluid range for your patient.

ImpediMed SOZO HF-Dex Analysis for Heart Failure Objective Metric

Objective Measure of Fluid Volume

Heart failure (HF), also known as congestive heart failure or chronic heart failure (CHF), affects ~26 million people globally. Current monitoring technologies such as weight scales or implantable pulmonary artery pressure (PAP) monitors are either inaccurate or require invasive procedures.

The SOZO® Digital Health Platform with HF-Dex™ offers a fast, accurate, and non-invasive measurement of fluid burden to better monitor and manage heart failure patients at the point-of-care.

HF-Dex Analysis for Heart Failure

ImpediMed’s sophisticated BIS technology ensures high quality, objective fluid volume measurements, every time.

  • HF-Dex heart failure index provides a measure of fluid status
  • Total Body Water (TBW) volume accounts for all of the water in the body.
  • Extracellular Fluid (ECF) volume includes the water outside of cells.
  • Intracellular Fluid (ICF) volume includes the water inside of cells.
  • Weight

Learn more about HF-Dex

Fluid Volume and Heart Failure

Reduced cardiac function in heart failure patients leads to a buildup of extracellular fluid. The optimal fluid volume can vary from patient to patient and change with disease progression.


  • Measure of fluid volume in heart failure patients: extracellular fluid as percent of total body water
  • Consistent and objective metric, free of inter-observer error
  • Tracks fluid retention and loss that are not visible with weight alone

Total Body Water

  • 60% of human body is water1
  • Varies based on age, gender, body size, and composition
  • Maintained by homeostasis
  • Impacted by normal weight gain or loss as well as disease conditions

Intracellular Fluid2,3

  • Majority of body water in healthy adults
  • Muscle contains ~75% water and makes up ~50% lean body mass
  • Decreases in ICF are associated with decreases in muscle mass

Extracellular Fluid4

  • Stored in intravascular and interstitial spaces
  • Reduced cardiac function in HF patients lead to fluid volume increase
  • Extent of ECF can vary from patient to patient and change with disease progression

Contact Us

Contact us to learn more about SOZO with HF-Dex and the benefits of implementing an objective measure of fluid volume for your heart failure patients.

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  1. Serra-Prat M, et al. Intracellular Water Content in Lean Mass is Associated with Muscle Strength, Functional Capacity, and Frailty in Community-Dwelling Elderly Individuals. A Cross-Sectional Study. Nutrients 2019;doi:10.3390/nu11030661.
  2. Serra-Prat M, et al. Total Body Water and Intracellular Water Relationships With Muscle Strength, Frailty and Functional Performance in an Elderly Population. J Nutr Health Aging . 2019;23(1):96-101.
  3. Capillary Fluid Exchange: Regulation, Functions, and Pathology. Scallan J, Huxley VH, Korthuis RJ. San Rafael (CA): Morgan & Claypool Life Sciences; 2010.