NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Survivorship

Magee-Womens Hospital of UPMC Adopts L-Dex® Testing for Lymphedema Prevention Program

ImpediMed’s L-Dex<sup>®</sup> Technology Used to Aid in the Clinical Assessment and Monitoring of Female Breast Cancer Patients at Risk for Lymphedema

BRISBANE, Australia and PITTSBURGH, Nov. 23, 2010 /PRNewswire/ — ImpediMed Limited and Magee-Womens Hospital (Magee) of UMPC today jointly announced Magee’s plan to utilize ImpedMed’s L-Dex® technology in its newly-launched Lymphedema Screening, Early Detection and Prevention Program (LESEP). The L-Dex technology serves as an aid in the clinical assessment of breast cancer patients at risk of developing lymphedema.

The program, under the direction of Atilla Soran, M.D., M.P.H., professor of surgery with the University of Pittsburgh School of Medicine and a practicing surgeon with Magee-Womens Surgical Associates, will incorporate a prospective model of care with pre-surgical baseline testing and quarterly surveillance of patients in order to identify early onset of lymphedema, which is the most effective time to treat the disease.

“The progressive nature of lymphedema mandates that we utilize emerging technologies to identify and treat the disease as early as possible,” said Dr. Soran, who initiated a specialized clinic in 2005 to provide assessment, consultation and treatment to patients with lymphedema. “Since there is no cure for lymphedema, risk identification and prevention are key. The bioimpedance spectroscopy (BIS) technology used in L-Dex assessment has been shown to be very sensitive in detecting the fluid changes characteristic of early stage lymphedema. Together with patient education and other advances in treatment, our program will provide breast cancer patients with state-of-the-art care to protect their quality of life while lowering the financial cost of treating lymphedema.”

Magee is being recognized as an inaugural member of ImpediMed’s new U.S. Lymphedema Centers of Excellence Program. ImpediMed’s Centers of Excellence Program will recognize and collaborate with academic medical institutions across the U.S. in establishing a pre-emptive model of lymphedema care utilizing its cleared medical device.

“We are excited to see a highly respected academic center such as Magee adopt BIS as the core assessment methodology in its Lymphedema Program,” said Greg Brown, CEO of ImpediMed. “This provides validation of the pre-emptive model of care through the incorporation of a standardized and objective metric for aiding in the clinical assessment of extracellular fluid volume differences between the arms of female breast cancer patients. We applaud Magee’s initiative to address this important aspect of survivorship and welcome them among our first Centers of Excellence.”

Magee sees nearly 2,700 new cancer patients per year, 90 percent of which are breast cancer, gynecologic cancer and melanoma patients. Lymphedema is a chronic and progressive condition that can lead to a swollen limb deformity caused by the obstruction to the flow of lymphatic fluid.

More than 20 percent of cancer patients who have lymph node dissections or receive radiation therapy to their lymph nodes are at risk for developing lymphedema. In the United States, the highest incidence of lymphedema occur following breast cancer surgery, with between six and 30 percent of patients developing some degree of surgery site upper extremity lymphedema.

Some patients experience symptoms of swelling immediately following surgery or radiation while others do not experience symptoms for weeks, months, or even years. Worldwide, it is estimated that there are 140 to 250 million cases of lymphedema.

About ImpediMed

Founded and headquartered in Brisbane, Australia with U.S. offices in Carlsbad, Calif., and Bloomington, Minn., ImpediMed is the world leader in the development and distribution of medical devices employing bioimpedance spectroscopy (BIS) technologies for use in the noninvasive clinical assessment and monitoring of fluid status in patients. ImpediMed has the first medical device with FDA clearance in the U.S. to aid healthcare professionals to clinically assess secondary unilateral lymphedema of the arm and leg in women and the leg in men.

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