Clinical evidence | ImpediMed - Part 2

Clinical evidence

ImpediMed’s bioimpedance spectroscopy (BIS) devices have been studied and clinically validated in the areas of lymphedema, heart failure, body composition and veterinary BIS research.

Heart failure
Lymphedema prevention
L-Dex detection limit
Validation studies
Economics quality of life

Andrew J. Accardi, MD, James Thomas Heywood, MD, FACC, Anne Daleiden-Burns, ACNP

Bioimpedance Spectroscopy: a Predictor of Compensated Versus Decompensated Heart Failure in the Emergency Room

ECF%TBW has been shown to be a marker of fluid overload in patients presenting with dyspnea. Median ECF%TBW for decompensated, compensated, and control were 52.1%, 49.0%, and 44.8%, respectively. Statistically significant ECF%TBW differences were shown. This bedside BIS device provides instantly useful quantitative fluid status data at the point-of-care. When coupled with physical exam and traditional markers, BIS may provide additional value to assist in ER evaluation and triage, as well as other settings in which fluid status is monitored.

Open access: YES
ONS Guidelines™

ONS Guidelines for Cancer Treatment-Related Lymphedema

Early diagnosis and treatment of lymphedema may mitigate symptoms.

Open access: Yes
Sheila H. Ridner, Chirag Shah, John Boyages, Louise Koelmeyer, Nicolas Ajkay, Sarah M. DeSnyder, Sarah A. McLaughlin, Mary S. Dietrich

L-Dex, arm volume, and symptom trajectories 24 months after breast cancer surgery

These data support the need for long-term (24 months) prospective surveillance with frequent assessments (every 3 months) at least 15 months after surgery. Statistically significant convergence of symptom cluster scores with L-Dex unit change supports BIS as beneficial in the early identification of subclinical lymphedema.

Open access: Yes
Academy of Oncologic Physical Therapy of APTA

Interventions for Breast Cancer-Related Lymphedema: Clinical Practice Guidelines From the Academy of Oncologic Physical Therapy of APTA

From the American Physical Therapy Association, recent guidelines include a prospective surveillance model and early, preventative intervention for patients at risk of cancer-related lymphedema.

Open access: Yes
Lymphatic Education & Research Network

Centers of Excellence Program Description and Application

Bioimpedance spectroscopy as a tool for serial measurement and risk assessment

Open access: Yes
Coroneos, C.J., et al.

Correlation of L-Dex Bioimpedance Spectroscopy with Limb Volume and Lymphatic Function in Lymphedema

The L-Dex ratio correlated with limb volume and clinical assessment of pitting edema, and physiologic measures of lymphatic function, and demonstrated face, construct, and criterion validity in response to intervention. These findings support the adjunctive use of the L-Dex ratio with limb volume measurements for objective diagnosis, evaluation of lymphedema severity, longitudinal serial evaluation of lymphedema, and response to conservative and surgical interventions.

Open access: No
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SOZO, the world’s most advanced, noninvasive BIS device, incorporates L-Dex technology to aid in the assessment of secondary lymphedema and delivers a precise snapshot of fluid status and tissue composition in less than 30 seconds.

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